Every iOS firmware update is sure to present a concern for most jailbreak users. Every firmware update comes with a good deal of features and improvements that will prove to be attractive for most iOS users. On the other hand, jailbreakers will have to wonder if the latest firmware will work with their jailbreak solution. Such is the dilemma that jailbreakers will have to contend with every time a new firmware update is available. As we have reported earlier, Apple has already rolled out the first-ever update to iOS 6 which is iOS 6.0.1 which comes with the usual bug fixes and performance enhancements. A word of advice: jailbreakers should stay away from iOS 6.0.1.
If you are a longtime jailbreak user, it should be a rule of thumb to hold off on upgrading to the latest available firmware update. This is for the fact that almost always, the update will surely patch the exploit that makes the jailbreak work. The latest iOS 6.0.1 is no exception. @Veeence seems to agree with this point as he warns his followers in Twitter to hold off on upgrading to iOS 6.0.1.
If you’re waiting for an (untethered) JB, don’t update to iOS 6.0.1, yet.
Again, this advice is pretty much a no-brainer for a jailbreak user but still there are those that accidentally update their device which leads to loss of jailbreak. As of this point, nothing is certain yet. iOS 6.0.1 might have brought some patches that eliminates the exploit which will be used for an untethered jailbreak in the future. Again nothing is confirmed yet aside from the fact that the iOS 6 untethered jailbreak is being actively worked on.
If you are really itching to update to iOS 6.0.1, then one option that you have is to save your iOS 6.0 blobs using Redsn0w's SHSH > New button and pointing to the 6.0 IPSW, as suggested by @MuscleNerd. This way, you can choose to downgrade to iOS 6.0, in case the need arises. However, if you are currently with iOS 6.0, MuscleNerd recommends that you stay in it for the meantime and wait for further development.
Save your 6.0 blobs with redsn0w's SHSH->New button (connect device 1st). Also I recommend staying at 6.0 *if* that's where you are now
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So to sum it up, we advice jailbreak users not to upgrade to iOS 6.0.1 just yet as it is possible that you may lose the chance to acquire the upcoming iOS 6 untethered jailbreak in the future. You might want to wait for more news from prominent jailbreak hackers if it is safe to update. As a safety precaution, it is also recommended that you save your SHSH blobs using Redsn0w which by the way also works on the iPhone 5. With this, you can choose to downgrade from iOS 6.0.1 if ever you need to.